The network once boasted hosts such as Al Franken and Rachel Maddow, but struggled from the outset, including multiple management shake-ups, a bankruptcy in 2006 and sale for $4.25 million the following year.
Air America ceased airing new programs Thursday afternoon and said it will soon file to be liquidated under Chapter 7 bankruptcy. It began broadcasting reruns of programs and would end those as well Monday night.
"The very difficult economic environment has had a significant impact on Air America's business. This past year has seen a `perfect storm' in the media industry generally," the company said in a statement on its Web site.
The New York-based network said its "painstaking search for new investors" came close to succeeding even this week, "but ultimately fell short."